In my interview with world glutathione expert Dr Jimmy Gutman I accidentally asked a question. that had deeper implications than I realised.
I asked "If we call the outcome of low Vitamin D is Rickets, and the outcome of low vitamin C is called Scurvy, what do we call the outcome of low Glutathione?"
These are excerpts from a recent paper (Sept 28th 2022) nailing the connection between illness and low glutathione.
Low glutathione levels are associated with these 90 + diseases or conditions.
Acetaminophen poisoning / toxicity
ADD
Addison's Disease
Aging
AIDS
Alopecia Areata
ALS
Alzheimer's Disease
Anemia (hemolytic)
Ankylosing Spondylitis
Arteriosclerosis (hardening of the arteries)
Arthritis (rheumatoid)
Asthma
Autism (ASD)
Autoimmune disease
Behcet’s Disease
Blepharitis
Burns
Cachexia
Cancers
Candida infection
cardiomyopathy (idiopathic)
cardiovascular disease
Chronic Fatigue Syndrome
Colitis
COPD
Coronary artery disease
Cystic fibrosis
Diabetes
Crohn’s disease
Eczema
Emphysema
Epstein Barr Viral Syndrome (EBV)
Fibromyalgia
Free Radical Overload
Goodpasture Syndrome
Graves' Disease
Heavy Metal Toxicity
Hepatic dysfunction (liver disease)
Hepatitis B
Hepatitis C
Some day to be added to the list...
Hepatitis D
Hepatitis E
Hepatitis G
Hepatitis I
Hepatitis TT
Hepatitis SMA1
Hypercholesterolemia (high blood cholesterol)
Herpes
HIV Aid's
Huntington's Disease/ Huntington's Chorea
Infections (bacterial, viral, fungal)
Inflammatory bowel disease (IBD)
Influenza
Liver Disease
Lyme Disease
Lupus
Macular Degeneration (diabetic macular degeneration)
Malnutrition
Meniere’s Disease
Methylmercury poisioning
Multiple sclerosis (MS)
Myasthenia Gravis
Neurogenerative diseases
Noise Induced Hearing Loss
Nutritional Disorders
Obsessive Compulsive Disorder
Parkinson's disease
Pemphigus Vulgaris
Polycystic kidney disease
Polycystic ovary syndrome
Primary Billary Cirrhosis
Progeria
Psoriasis
Rheumatic Fever
Sarcoidosis
Scleroderma
Shingles
Stroke
Surgery
Thalassemia
Trichotillomania (Hair Pulling)
Toxic poisoning
Trauma
Unverricht-Lundborg Disease
Vasculitis
Veisalgia (when combined with vitamin C and B1)
Vitiligo
Wegener’s Granulomatosis
There are many more diseases which are not listed above, that are also associated with low glutathione.
To find out more on how to raise glutathione levels naturally, click for more info here.
The Role of Glutathione Metabolism in Chronic Illness Development and Its Potential Use as a Novel Therapeutic Target
Abstract
Low GSH levels have been associated with many chronic pro-inflammatory conditions, such as metabolic syndrome, cardiovascular, renal, and hepatic disease, as well as neurodegenerative conditions and autoimmune diseases.
Several large prospective studies support this hypothesis by demonstrating that higher GGT levels are correlated with the risk of developing metabolic syndrome and cardiovascular disease in a dose-dependent fashion.
Human and animal trials utilizing GSH augmentation using precursor supplementation in chronic conditions, including metabolic syndrome, cardiovascular disease, hepatic disease, renal disease, and neurodegenerative conditions, were also reviewed.
There is strong evidence that GSH supplementation leads to improved outcomes in all of these chronic conditions.
This review seeks to highlight the role of GSH in chronic disease progression because a simple and cost-effective strategy can be created to screen for, track, and intervene in susceptible patients at the earliest possible time in the disease process.
Such a novel strategy would impact the majority of chronic diseases contributing to the bulk of morbidity and mortality in the Western world, and, thus, even minor benefits across many conditions may substantially impact population-wide health and longevity.
The biochemical role of glutathione as a driver of chronic illness
Low total GSH levels and elevated ratios of oxidized to reduced GSH are common in chronic illnesses as well as advanced age.
While these relationships have been known for years, most literature has overlooked these findings as the predictable result of increased inflammation and oxidative stress similar to other biomarkers such as C-reactive protein (CRP).
Few, if any, studies have explored the possibility of low GSH levels as a potentially important causative driver of disease pathology in itself
Papers Conclusions
GSH is a key thiol antioxidant in the human body which, among its many functions, serves as a major mitochondrial protector, and through this function is linked to many chronic illnesses which make up the bulk of the healthcare burden in Western societies today.
Studies presented in this review show that low GSH levels have a demonstrable correlation to the faster onset of these chronic diseases and increased mortality.
The study above mentions NAC which is basically manmade cysteine.
Most NAC is made from recycled human hair.
NAC can become toxic, having the reverse effect becoming oxidative.
There is a better way of introducing natural highly bioavailable cysteine - more info here.
References to the paper above
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