Low glutathione levels are associated with many diseases or conditions.

Before we list 90 of them, here are some highlights from this recent study released on the 28th September 2022.

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Abstract

Low GSH levels have been associated with many chronic pro-inflammatory conditions, such as metabolic syndrome, cardiovascular, renal, and hepatic disease, as well as neurodegenerative conditions and autoimmune diseases.

 

Several large prospective studies support this hypothesis by demonstrating that higher GGT levels are correlated with the risk of developing metabolic syndrome and cardiovascular disease in a dose-dependent fashion.

 

Human and animal trials utilizing GSH augmentation using precursor supplementation in chronic conditions, including metabolic syndrome, cardiovascular disease, hepatic disease, renal disease, and neurodegenerative conditions, were also reviewed.

 

There is strong evidence that GSH supplementation leads to improved outcomes in all of these chronic conditions.

 

This review seeks to highlight the role of GSH in chronic disease progression because a simple and cost-effective strategy can be created to screen for, track, and intervene in susceptible patients at the earliest possible time in the disease process.

 

Such a novel strategy would impact the majority of chronic diseases contributing to the bulk of morbidity and mortality in the Western world, and, thus, even minor benefits across many conditions may substantially impact population-wide health and longevity.

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The biochemical role of glutathione as a driver of chronic illness

Low total GSH levels and elevated ratios of oxidized to reduced GSH are common in chronic illnesses as well as advanced age.

 

While these relationships have been known for years, most literature has overlooked these findings as the predictable result of increased inflammation and oxidative stress similar to other biomarkers such as C-reactive protein (CRP).

 

Few, if any, studies have explored the possibility of low GSH levels as a potentially important causative driver of disease pathology in itself

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Conclusions

GSH is a key thiol antioxidant in the human body which, among its many functions, serves as a major mitochondrial protector, and through this function is linked to many chronic illnesses which make up the bulk of the healthcare burden in Western societies today.

 

Studies presented in this review show that low GSH levels have a demonstrable correlation to the faster onset of these chronic diseases and increased mortality.

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SOURCE: https://www.cureus.com/articles/92153-the-role-of-glutathione-metabolism-in-chronic-illness-development-and-its-potential-use-as-a-novel-therapeutic-target?

 

The study above mentions NAC which is basically manmade cysteine.

Most NAC is made from recycled human hair.

NAC can become toxic, having the reverse effect becoming oxidative.

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There is a better way of introducing natural highly bioavailable cysteine - more info here.

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Low glutathione levels are associated with these 90 + diseases or conditions.

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1. Acetaminophen poisoning / toxicity

2. ADD

3. Addison's Disease

4. Aging

5. AIDS

6. Alopecia Areata

7. ALS

8. Alzheimer's Disease

9. Anemia (hemolytic)

10. Ankylosing Spondylitis

11. Arteriosclerosis (hardening of the arteries)

12. Arthritis (rheumatoid)

13. Asthma

14. Autism (ASD)

15. Autoimmune disease

16. Behcet’s Disease

17. Blepharitis

18. Buerger's Disease

19. Burns

20. Cachexia

21. Cancers

22. Candida infection

23. cardiomyopathy (idiopathic)

24. cardiovascular disease

25. Chronic Fatigue Syndrome

26. Colitis

27. COPD

28. Coronary artery disease

29. Cystic fibrosis

30. Diabetes

31. Crohn’s disease

32. Eczema

33. Emphysema

34. Epstein Barr Viral Syndrome (EBV)

35. Fibromyalgia

36. Free Radical Overload

37. Goodpasture Syndrome

38. Graves' Disease

39. Heavy Metal Toxicity

40. Hepatic dysfunction (liver disease)

41. Hepatitis B

42. Hepatitis C

43. Some day to be added to the list...

44. Hepatitis D

45. Hepatitis E

46. Hepatitis G

47. Hepatitis I

48. Hepatitis TT

49. Hepatitis SMA1

50. Hypercholesterolemia (high blood cholesterol)

51. Herpes

52. HIV Aid's

53. Huntington's Disease/ Huntington's Chorea

54. Infections (bacterial, viral, fungal)

55. Inflammatory bowel disease (IBD)

56. Influenza

57. Liver Disease

58. Lyme Disease

59. Lupus

60. Macular Degeneration (diabetic macular degeneration)

61. Malnutrition

62. Meniere’s Disease

63. Methylmercury poisioning

64. Multiple sclerosis (MS)

65. Myasthenia Gravis

66. Neurogenerative diseases

67. Noise Induced Hearing Loss

68. Nutritional Disorders

69. Obsessive Compulsive Disorder

70. Parkinson's disease

71. Pemphigus Vulgaris

72. Polycystic kidney disease

73. Polycystic ovary syndrome

74. Primary Billary Cirrhosis

75. Progeria

76. Psoriasis

77. Rheumatic Fever

78. Sarcoidosis

79. Scleroderma

80. Shingles

81. Stroke

82. Surgery

83. Thalassemia

84. Trichotillomania (Hair Pulling)

85. Toxic poisoning

86. Trauma

87. Unverricht-Lundborg Disease

88. Vasculitis

89. Veisalgia (when combined with vitamin C and B1)

90. Vitiligo

91. Wegener’s Granulomatosis

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There are many more diseases which are not listed above, that are also associated with low glutathione.

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To find out more on how to raise glutathione levels naturally, click for more info here.

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